Endocrine Abstracts

Background: Detection of MRI-negative ACTH-producing pituitary adenomas is a challenge inthe management of patients with Cushing’s disease. There are some data on theability of pituitary adenomas to accumulate 18F-fluorodeoxyglucose during the 18F-FDG positron emission tomography and computer tomography (18F-FDG PET/CT). Aim: To study the potential of using a standardized uptake value (SUV) and a tumor &...

Background: Management of primary hyperparathyroidism (PHPT) in Multiple Endocrine Neoplasia type 1 syndrome (MEN 1) is still a challenge. PHPT developing in MEN 1 is characterized by the involvement of all parathyroid glands. Therefore, by modern guidelines, total or subtotal removal of the parathyroid glands is recommended. But this approach often leads to the development of hypoparathyroidism, adequate correction of which is not always possible. Drug therapy of recurrent PH...

Background: Detection of MRI-negative ACTH-producing pituitary adenomas is a challenge in the management of patients with Cushing’s disease. There are some data on the possibility of pituitary adenomas to accumulate 18F-fluorodeoxyglucose (18F-FDG) during the 18F-FDG positron emission tomography and computer tomography (18F-FDG PET/CT).Aim: To study the potential of brain 18F-fluorodeoxyglucose PET/CT for localization of MRI-negative ACTH-producing ...

Introduction: Perioperative assessment of surgical outcome in acromegaly patients is essential due to significant persistence rate even after total adenomectomy. Grade of adenoma invasiveness and basal growth hormone (GH) level in early postoperative period have been considered as important factors.Aim: The aim of our study was to evaluate the correlation between the outcomes of surgery in patients with acromegaly and the grade of adenoma invasion assess...

Purpose: According to modern guidelines late night serum cortisol measurement is not considered to be among the first steps for screening of hypercortisolism. But in some cases it may be useful as it allows identifying the loss of normal circadian rhythm of cortisol secretion. This test is not rarely used in hospitalized patients when Cushing’s syndrome is suspected. But the cutt-off point of nighttime serum cortisol level for the diagnosis of hypercortisolism is inconsis...

Aim: The aim of our study was to assess the contribution of genetic variation in some previously reported gestational diabetes mellitus (GDM) susceptibility loci and lifestyle parameters to GDM risk.Methods: We performed a case-control study of 278 GDM cases and 179 controls who had filled up special questionnaires concerning their lifestyle habits during the oral glucose tolerance test (OGTT) on the 24–32 week of gestation. The questionnaire consis...

Introduction: Transsphenoidal surgery (TSS) is the treatment of choice for patients with acromegaly. However, even after radical surgery persistence of acromegaly may remain up to thirty percent by resent studies (Starnoni, 2016). Nadir growth hormone (GH) level less than 1.0 μg/l on an early postoperative oral glucose tolerance test (OGTT) have been suggested as early predictor of surgical remission (Kim 2012). However, the value of this approach remains to be defined.</...

Purpose: Transsphenoidal endoscopic surgery (TSS) is the first-line treatment for Cushing’s disease (CD). Persistence and recurrence of hypercortisolism after TSS considered important problem. In this case search for CD remission predictors is actual.Aim: To study the role of preoperative oral high-dose dexamethasone suppression test (HDDST) in the prognosis of CD remission after TSS.Materials and methods: 60 patients with Cus...

Purpose: Transsphenoidal endoscopic surgery (TSS) is the first-line treatment for Cushing’s disease (CD). However, persistence and recurrence of hypercortisolism after TSS considered important problem. In this case search for CD remission predictors is actual.Aim: To study the role of preoperative oral high-dose dexamethasone suppression test (HDDST) and pituitary MRI in the prognosis of CD remission after TSS.Materials and me...

Purpose: Hypertension is an independent factor of cardiovascular morbidity in acromegaly patients. Obstructive sleep disordered breathing (SDB) is the most common respiratory impairment in acromegaly and is considered one of the mechanisms underlying the development of hypertension in this disorder.Aim: To study blood pressure parameters and prevalence of hypertension in naïve acromegaly patients depending on the presence of moderate-to-severe obstr...